Javier Cuevas Selected Research

2- ((2- morpholino)ethylthio)- 5- ethoxybenzimidazole

1/2019	Activation of Sigma Receptors With Afobazole Modulates Microglial, but Not Neuronal, Apoptotic Gene Expression in Response to Long-Term Ischemia Exposure.
11/2016	Activation of σ1 and σ2 receptors by afobazole increases glial cell survival and prevents glial cell activation and nitrosative stress after ischemic stroke.
10/2011	Afobazole modulates microglial function via activation of both sigma-1 and sigma-2 receptors.
10/2011	Afobazole modulates neuronal response to ischemia and acidosis via activation of sigma-1 receptors.

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Javier Cuevas Research Topics

Disease

11	Ischemia 01/2021 - 12/2006
7	Stroke (Strokes) 01/2021 - 05/2006
6	Ischemic Stroke 01/2021 - 05/2006
5	Acidosis 01/2021 - 07/2010
3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 11/2016 - 05/2006
3	Infarction (Infarctions) 01/2013 - 05/2006
2	Multiple Myeloma 01/2017 - 06/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2013 - 10/2007
2	Ganglion Cysts (Ganglion) 11/2009 - 06/2002
1	Thrombosis (Thrombus) 02/2021
1	Acute Coronary Syndrome 01/2021
1	Hypertension (High Blood Pressure) 01/2021
1	Hepatocellular Carcinoma (Hepatoma) 01/2021
1	Heart Failure 01/2021
1	Atrial Fibrillation 01/2018
1	Neuroinflammatory Diseases 11/2016
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/2011
1	Brain Ischemia (Cerebral Ischemia) 07/2010
1	Spinal Cord Injuries (Spinal Cord Injury) 10/2007
1	Hypertrophy 07/2006
1	Cardiomegaly (Heart Hypertrophy) 07/2006
1	Embolic Stroke 05/2006
1	Alzheimer Disease (Alzheimer's Disease) 10/2004
1	Schizophrenia (Dementia Praecox) 10/2004

Drug/Important Bio-Agent (IBA)

8	sigma Receptors (sigma Receptor)IBA 01/2019 - 06/2002
6	CalciumIBA 02/2014 - 07/2006
4	2- ((2- morpholino)ethylthio)- 5- ethoxybenzimidazoleIBA 01/2019 - 10/2011
2	Acid Sensing Ion ChannelsIBA 01/2021 - 07/2010
2	LigandsIBA 11/2016 - 01/2013
2	Glucose (Dextrose)FDA LinkGeneric 02/2014 - 12/2006
2	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2013 - 05/2006
2	Guanidine (Guanidine Nitrate)FDA Link 01/2013 - 03/2010
2	N- (2- (3,4- Dichlorphenyl)ethyl)- N,N',N'- trimethyl- 1,2- ethandiaminIBA 10/2011 - 12/2006
2	metaphitIBA 10/2011 - 12/2006
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 07/2010 - 12/2006
2	Ion Channels (Ion Channel)IBA 11/2009 - 11/2008
1	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2021
1	Ethacrynic Acid (Etacrynic Acid)FDA Link 01/2021
1	Bumetanide (Bumex)FDA LinkGeneric 01/2021
1	Sorafenib (BAY 43-9006)FDA Link 01/2021
1	Potassium Chloride FDA LinkGeneric 01/2021
1	SodiumIBA 01/2021
1	Carrier Proteins (Binding Protein)IBA 01/2021
1	omega-Chloroacetophenone (Mace)IBA 01/2021
1	Peptide Hydrolases (Proteases)FDA Link 01/2019
1	Apoptosis Regulatory ProteinsIBA 01/2019
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2019
1	Caspase 3 (Caspase-3)IBA 01/2019
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2018
1	PotassiumIBA 01/2018
1	PeptidomimeticsIBA 01/2017
1	MTI-101IBA 01/2017
1	benzimidazoleIBA 11/2016
1	S-nitrosocysteineIBA 11/2016
1	MorpholinosIBA 11/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2016
1	AzidesIBA 02/2014
1	phenyl-N-tert-butylnitroneIBA 02/2014
1	Butylated Hydroxytoluene (BHT)IBA 02/2014
1	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA 02/2014
1	1- (2- (3,4- dichlorophenyl)ethyl)- 4- methylpiperazineIBA 10/2011
1	Adenosine Triphosphate (ATP)IBA 10/2011
1	Purinergic Receptors (Receptors, Purine)IBA 10/2011
1	Farnesyltranstransferase (Farnesyltransferase)IBA 06/2011
1	Bortezomib (Velcade)FDA Link 06/2011
1	tipifarnib (R115777)IBA 06/2011
1	Nifedipine (Adalat)FDA LinkGeneric 07/2010
1	Tetrodotoxin (Tetradotoxin)IBA 07/2010
1	Protons (Proton)IBA 07/2010
1	2-Amino-5-phosphonovalerate (2 Amino 5 phosphonovalerate)IBA 07/2010
1	GuanidinesIBA 03/2010
1	IodidesIBA 03/2010
1	CopperIBA 03/2010
1	Potassium Channels (Potassium Channel)IBA 11/2009
1	Voltage-Gated Sodium ChannelsIBA 11/2009
1	CatecholaminesIBA 07/2009
1	Carvedilol (Coreg)FDA LinkGeneric 07/2009
1	Prazosin (Minipress)FDA LinkGeneric 07/2009
1	beta Adrenergic ReceptorsIBA 07/2009
1	Sigma-1 ReceptorIBA 12/2006
1	carbetapentane (pentoxyverine)IBA 12/2006
1	ethylamineIBA 12/2006
1	Pentazocine (Talwin)FDA LinkGeneric 12/2006
1	Ibogaine (Endabuse)IBA 12/2006
1	piperidineIBA 12/2006
1	2- (4- morpholino)ethyl- 1- phenylcyclohexane- 1- carboxylateIBA 12/2006
1	Sodium AzideIBA 12/2006
1	Cocaine (Cocaine HCl)IBA 07/2006
1	KN 62IBA 07/2006
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 07/2006
1	Proteins (Proteins, Gene)FDA Link 07/2006
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 07/2006
1	fluoro jadeIBA 05/2006
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 10/2004

Therapy/Procedure

5	Therapeutics 02/2013 - 10/2007
1	Transcatheter Aortic Valve Replacement 02/2021
1	Drug Therapy (Chemotherapy) 06/2011
1	Splenectomy 07/2009
1	Denervation 07/2009
1	Subcutaneous Injections 05/2006